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1994-10-25
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Document 2919
DOCN M94A2919
TI Hypocholesterolemia and psychological distress in HIV-1 disease.
DT 9412
AU Shor-Posner G; Feaster D; Blaney N; Miguez-Burbano M; Goodkin K;
Elsdorfer C; Baum MK; Department of Epidemiology, University of Miami
School of; Medicine, FL.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):195 (abstract no. PB0208). Unique
Identifier : AIDSLINE ICA10/94369656
AB OBJECTIVE: Altered serum lipid concentrations, (hypertriglyceridemia,
hypocholesterolemia) which have been documented in HIV-1 disease, have
been associated with behavioral abnormalities. The present study
determined the relationship between lipid status and psychosocial
behavior in 118 HIV seropositive (CDC Stages II, III n = 96; CDC Stage
IV 2A n = 22) and 52 seronegative homosexual men. METHODS: Extracted
serum was saponified, followed by oxidation condensation reactions to
produce a fluorescing compound for triglyceride analysis. Levels of
cholesterol were similarly obtained from serum extracts after reaction
with Lieberman-Buchard color reagent, and read as absorbance at 630 nm
(Technicon Auto Analyzer II). Psychological distress was measured with
the Profile of Mood States. RESULTS: Hypocholesterolemia (< 150 mg/dl)
was observed in 41% of the infected men and 24% of the controls.
Analysis of variance, controlling for HIV-1 status, indicated
significantly higher distress in subjects with low cholesterol as
compared to subjects with serum cholesterol levels in the normal range
(p < 0.026). In addition, a significant interaction between stress and
hypocholesterolemia was observed in a model of psychological distress,
which included stress, coping style and social support (p < .043).
Hypertriglyceridemia (> 160 mg/dl), occurred in 11% of the seropositives
and 19% of the seronegatives, but, was not associated with elevated
distress. DISCUSSION AND CONCLUSIONS: The significant association
between hypocholesterolemia and psychological distress supports the
suggestion that altered lipid status may be linked to disturbances in
behavior.
DE Adaptation, Psychological Affect Affective Disorders/BLOOD/*ETIOLOGY
Cholesterol/BLOOD/*DEFICIENCY Human Hypertriglyceridemia/PSYCHOLOGY
HIV Infections/*BLOOD/PSYCHOLOGY *HIV-1 Male Social Support MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).